If we look at history of physics, is there a clear trend to allow us to guess its future?
What are the major milestones in physics history?
I think it could be said:
1) Ancient Greece (level) Physics
2) Galileo (level) Physics
3) Newton (level) Physics
4) Einstein (level) Physics
5) TOE (level) Physics(?)
I think there is indeed a clear trend if you think about it.
Each new revolution in physics brings something like an order of magnitude increase in complexity of math (calculations), not just a new theory.
So I would guess doing calculations to solve physics problems using TOE will be practically impossible using pen and paper only.
I think it will require a (quantum) computer.
(Realize that all physics problems (where answer is possible) can be solved today using non-quantum (super) computers/calculators/pen&paper.)
I think if Universe (or Reality) turns out to be a Cellular Automata design running on an ND matrix qubit (register) quantum computer (with Planck scale cells)
then it would fit into above guess about future of physics (TOE) perfectly.